Berbatov has suffered a recurrence of an old groin injury and will be unavailable for two weeks, while defender Kaboul faces a possible month out of action with a hamstring strain.
Spurs have endured a poor start after losing their opening game to Sunderland and then crashing 3-1 at home to Everton on Tuesday night.
Manager Martin Jol also has a burgeoning injury list to consider, with Berbatov and Kaboul joining Ledley King, Michael Dawson, Aaron Lennon, Gareth Bale and Lee Young-Pyo on the sidelines.
"We've had a couple more blows," said Jol.
"Younes Kaboul will be out for the next three or four weeks with the hamstring injury he suffered against Everton, that's a real kick in the teeth and Dimitar Berbatov has a groin problem.
"It's an old problem and he will now visit a specialist in Germany. He will be out for a couple of weeks."
However, Jol is optimistic he will soon be able to select Young-Pyo and Bale.
"Gareth Bale is looking better," Jol added.
"Our medical team have also told me that Young-Pyo Lee is up to 85 per cent fitness and that will soon be 100 per cent."