Beckham is scheduled to make the five-hour round trip from Los Angeles to appear at the showpiece encounter which will see the MLS All-Stars take on Scottish champions Celtic at Dick's Sporting Goods Park.
The England midfielder is to be introduced to a sell-out crowd and also take part in a television interview with national cable sports network ESPN.
But with Beckham's intended Los Angeles Galaxy debut against Chelsea on Saturday night in doubt following his slow recovery from ankle ligament damage, there are fears that airline travel could further exacerbate the problem.
Beckham has been rated by Galaxy coach Frank Yallop as having a 50-50 chance of playing at the weekend and the club's media relations staff said on Wednesday there had been no change in that assessment.
And Major League Soccer commissioner Dan Garber is keen not to do anything to jeopardise Beckham's chances of making the Blues clash.
He said: "If for any reason either he or his coaching, technical or training staff didn't think that the trip was in is interests then there is no way would we encourage him to do so."
The commissioner also added there was there no need for the Galaxy to risk playing Beckham before he had made a full recovery.
"There is no rush to play him on Saturday," Garber said. "David Beckham has signed a long-term contract and we just have to be sure he's healthy.
"David playing football is the priority, absolutely, and there is no pressure from a commercial standpoint on David Beckham or on any player in Major League Soccer."
Garber used his annual State Of The League address to announce that the San Jose Earthquakes would be reforming to expand the MLS to 14 teams from next season, two years ahead of schedule.
The Earthquakes were resurrected by Californian businessman Lew Wolff, a co-owner of the Oakland Athletics Major League Baseball club.
The two-time MLS champions left the league at the end of the 2005 season as the franchise was moved to Houston.
The new rights holders to the franchise were required to lodge a
20 million bond with the MLS and must now press ahead with plans to build a new stadium in time for the April 2008 kick-off.