Jose Mourinho's men travel to Los Angeles on Monday, with France midfielder Malouda in London to complete a medical and discuss personal terms after a fee was agreed with Lyon.
"Chelsea can confirm it has agreed a fee with Olympique Lyonnais for the transfer of Florent Malouda," read a statement from Chelsea.
The fee is undisclosed but Malouda has been valued at upwards of £13million in the French media since impressing for his country at the World Cup last year and featuring in the Champions League for Lyon.
Lyon president Jean-Michel Aulas confirmed after his team's friendly with Lille on Sunday night that an agreement had been reached.
"It (the deal) is brilliant and it is good news for Flo," Aulas told OLTV, the French champions' own television station.
"I have just called him. He is going to leave here and have a medical in London on Monday."
A statement on Lyon's official website added: "The transfer will only be made official after confirmation from the medical."
Ballack, 30, has not been ruled out of the entire tour but will not be with the squad for the first week following his operation in Europe last week.
"A decision will be taken later, depending on progress, about whether he will join the squad for the latter part of the tour," said Chelsea in a statement.
Even without Ballack in America, Mourinho's squad is taking shape, with Malouda set to be added to the summer first-team signings of Steve Sidwell, Claudio Pizarro and Tal Ben Haim.
Alex is tipped to join from PSV Eindhoven, and chief executive Peter Kenyon has stressed that Malouda's arrival does not compromise Arjen Robben's position at Stamford Bridge.
There are also hopes of Frank Lampard and John Terry committing their long-term futures to the club by signing new contracts.
Behind the scenes, former Israel boss Avram Grant has been appointed as director of football.
He will be working closely with Mourinho, the club confirmed, as well as Kenyon and Frank Arnesen, who oversees youth development.
As a widely reported friend of owner Roman Abramovich, Grant's arrival had been expected following his year at Portsmouth as technical director.
"Grant will be responsible for liaison on, and co-ordination of, football matters across the various areas of Chelsea," read a statement from Chelsea.
"He will also sit on the football club board and report to chief executive Peter Kenyon."
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