The Ukraine international has not travelled with the squad and joins Ricardo Carvalho (knee) and Michael Ballack (ankle) on the sidelines.
However, Arjen Robben is included in the squad after making a quicker-than-expected recovery from knee ligament damage.
Michael Essien will be available after a one-match European ban for the Anfield clash.
Didier Drogba is one yellow card away from missing a potential final in Athens if Chelsea can hold onto their 1-0 first-leg lead, while it is expected that Khalid Boulahrouz could come into defence.
Chelsea (from): Cech, A Cole, Makelele, Terry, Essien, Ferreira, Boulahrouz, Lampard, J Cole, Drogba, Mikel, Geremi, Bridge, Robben, Wright-Phillips, Diarra, Kalou, Cudicini.